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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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MathWorks Inc dcnn model
Simulations in identical conditions in both MATLAB ® <t>SimBiology</t> ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.
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Simulations in identical conditions in both MATLAB ® SimBiology ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.

Journal: bioRxiv

Article Title: A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience

doi: 10.1101/2020.11.17.385203

Figure Lengend Snippet: Simulations in identical conditions in both MATLAB ® SimBiology ® and COPASI yielded almost identical results. (A) Inputs used in both simulators. The calcium input is kept constant at 4 s for all simulations and dopamine input time is varied from time 0 to 8 s at every one second. The difference from the previous simulations is in the calcium input which, for the sake of simplicity, is represented by a double exponential spike. (B) and (C) show substrate phosphorylation curves analogous to , the red line represents results obtained in MATLAB ® and blue line results from simulations in COPASI.

Article Snippet: The bulk of our workflow is developed in MATLAB ® as it provides an easy-to-use biochemical modeling application with a graphical user interface called SimBiology ® along with a wide range of toolboxes for mathematical analysis.

Techniques: Phospho-proteomics